Additionally, these medications often cause stomach pain. In recent years, the FDA has issued stronger warnings about the increased risk of heart attack and stroke due to oral NSAIDs ( 3). Oral NSAIDs, such as ibuprofen, naproxen and aspirin, alleviate pain and swelling, but can increase blood pressure and exacerbate heart conditions. Topical NSAIDs, including gels, liquids and patches are as effective as oral NSAIDs, but generally carry fewer risks and side effects ( 2). Diclofenac gel can treat pain from a range of musculoskeletal conditions and has a favorable side effect profile relative to oral NSAID medications.
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